Coralie Fargeat, the director of The Substance, commented on the possibility of making a sequel to the 2024 massive horror hit and insisted that there will be “no sequels, no prequels.” The Substance is a horror film starring Demi Moore and Margaret Qualley that blew everyone’s mind in 2024 and even garnered some Award-season buzz. Critically acclaimed and very successful among fans of the bizarre, The Substance is a complete shift in tone that we didn’t know we needed.